Background
Diplom thesis in Industrial Chemistry –July
1983 University of Bologna (Italy)
Ph.D. Industrial Chemistry, December, 1987
Assistant Professor Industrial
Chemistry, October 1987
Visiting professor at Cornell University
(invited by Prof. C. K. Ober) and at the Martin Luter University of Friburg
(invited by Prof. W. Gronski)
Associate Professor Industrial Chemistry,
1998
Full Professor Industrial Chemistry and Polymeric Materials, 2006
Research Areas
Polymeric
Liquid Crystals. Chemical
concepts are introduced and exploited to tailor new liquid crystalline
polymeric materials to understand basic structure/property relationships
and meet demands of industrial applications
Mechanical
characterization of polymeric materials. Fundamental and applied studies on hydrogels,
block copolymers, polyesters, polyacrylates, networks and nanocomposites
Nanocomposites.
New nanostructured
materials based on commodity polymers and tailor-made organophylic clays
Polymer
nanoparticles and dispersions. Nanoparticles with new architectures, especially
core-shell type particles and their dispersions are prepared for
applications in structural parts and functional polymers
Chemical
reaction engineering: radical and catalytic controlled processes. Synthesis of new materials by living or
controlled anionic, cationic and free radical processes
TPO
and TPV elastomers. Synthesis
and thermomechanical characterization of polyurethane-based elastomers with
nanostructured morphology
Injection
molding and compression cutting technologies. Injection molding simulation and rheological
aspects related to the cutting-compression technology.
Prof. M. Laus is author of 164 papers in
International Journals and 8 patents.
Active Basic and Applied Projects
“Pre-clinical
evaluation of biocompatible nanoparticles as delivery system of
2O-methyl-phosphorothioate (2OMePS) antisense oligoribonucleotides for exon
skipping-mediated dystrophin restoration” GGP0909- 2010 TELETHON
PROJECTS
“Idrogeli polimerici
funzionali per la rigenerazione tissutale” 2011 CARIPLO PROJECTS
Industrial Projects supported by DIAB, Donegani-Enichem, Sacmi,
Solvay Solexis, TEUE Technoelastomers, TetraPak
Recent
Publications(2006-2010), Patents
Publications:
-Boarino L, Enrico E, De Leo N, Celegato F, Tiberto P,
Sparnacci K, Laus M (2010). Macro and Quasi-Mesoporous Silicon by
Self-Assembling and Metal Assisted Etching. Physica Status Solidi. A, Applications and
Materials Science, Issn: 1862-6300, Doi: 10.1002/Pssa.201000316
-Antonioli D, Laus M, Sparnacci K, Deregibus S,
Kapeliouchko V, Palamone G, Poggio T, Zuccheri G, Passeri R (2010). Thermal and DMA Characterization of
PTFE-PMMA Nanocomposites from Core-Shell Nanoparticles. Macromolecular Symposia, Vol. 296; P.
197-202, Issn: 1022-1360, Doi: 10.1002/Masy.201051029
-Ferlini A, Sabatelli P, Fabris M, Bassi E, Falzarano S,
Vattemi G, Perrone D, Gualandi F, Maraldi Nm, Merlini L, Sparnacci K, Laus
M, Caputo A, Bonaldo P, Braghetta P, Rimessi P (2010). Dystrophin Restoration in Skeletal, Heart
and Skin Arrector Pili Smooth Muscle of Mdx Mice By Zm2 Np-Aon Complexes. Gene Therapy, Vol. 17; P. 432-438, Issn:
0969-7128, Doi: 10.1038/Gt.2009.145
-Laus M, Sparnacci K, Antonioli D,
Deregibus S, Kapeliouchko V, Palamone G, Poggio T, Zuccheri G, Passeri R
(2010). On the Multiple Crystallization
Behavior of PTFE in PMMA/PTFE Nanocomposites from Core-Shell Nanoparticles. Journal Of Polymer Science. Part B,
Polymer Physics, Vol. 48; P. 548-554, Issn: 0887-6266
-Caputo, A, Castaldello, A, Brocca-Cofano, E, Voltan, R,
Bortolazzi, F, Altavilla, G, Sparnacci, K, Laus M, M, Tondelli, L,
Gavioli, R, Ensoli, B (2009). Induction
of Humoral and Enhanced Cellular Immune Responses by Novel Core-Shell Nanosphere-
and Microsphere-Based Vaccine Formulations Following Systemic and Mucosal
Administration.
Vaccine, Vol. 27; P. 3605-3615, Issn: 0264-410x
-Kapeliouchko, V, Palamone, G, Poggio, T, Zuccheri, G,
Passeri, R, Sparnacci, K, Antonioli, D, Deregibus, S, Laus M (2009).
PMMA-Based Core-Shell Nanoparticles
With Various PTFE Cores.
Journal of Polymer Science. Part A, Polymer Chemistry,
Vol. 47; P. 2928-2937, Issn: 0887-624x
-Monti, E, Gariboldi, M, Ravizza, R, Molteni, R,
Sparnacci, K, Laus M, M, Gabano, E, Ravera, M, Osella, D (2009). Poly(Methylmetacrylate) (PMMA) Core-Shell Nanospheres Act As Efficient
Pharmacophores For The Antiproliferative [Ptcl3(Nh3)]- Complex By Forming
Ionic Couples. Inorganica Chimica Acta, Vol. 362; P. 4099-4109,
Issn: 0020-1693
-Rimessi, P, Sabatelli, P, Fabris, M, Braghetta, P,
Bassi, E, Spitali, P, Vattemi, G, Tomelleri, G, Mari, L, Perrone, D,
Medici, A, Neri, M, Bovolenta, M, Martoni, E, Maraldi, N, Gualandi, F,
Merlini, L, Ballestri, M, Tondelli, L, Sparnacci, K, Bonaldo, P, Caputo, A,
Laus M, M, Ferlini, A (2009). Cationic Pmma Nanoparticles Bind and Deliver
Antisense Oligoribonucleotides Allowing Restoration of Dystrophin
Expression in the Mdx Mouse.
Molecular Therapy, Vol. 17; P. 820-827, Issn: 1525-0016
-Sparnacci, K, Antonioli, D, Deregibus, S, Laus M, Poggio, T, Kapeliouchko, V, Palamone, G,
Zuccheri, G, Passeri, R (2009). PTFE-Based Core‑Soft Shell Nanospheres and
Soft Matrix Nanocomposites.
Macromolecules, Vol. 42; P. 3518-3524, Issn: 0024-9297
-Monti, E, Gariboldi, M, Ravizza, R, Molteni, R, Gabano,
E, Sparnacci, K, Laus M, Osella, D
(2009). Assessment of the in Vivo
Antiproliferative Activity of a Novel Particulate Pharmacophore. In: A. Bonetti Et Al. Platinum And Other Heavy Metal Compounds In
Cancer Chemotherapy. , Doi: 10.1007/978-1-60327-459-3_3
-Voltan, R, Castaldello, A, Brocca-Cofano, E, De
Michele, R, Triulzi, C, Altavilla, G, Tondelli, L, Laus M, Sparnacci, K, Reali, E, Gavioli, R,
Ensoli, B, Caputo, A (2009). Priming
with a Very Low Dose of Dna Complexed With Cationic Block Copolymers
Followed by Protein Boost Elicits Broad and Long-Lasting Antigen-Specific
Humoral and Cellular Responses in Mice. Vaccine, Vol. 27; P. 4498-4507, Issn: 0264-410x
-Rimessi P, Sabatelli P, Fabris M, Braghetta P, Bassi E,
Spitali P, Vattemi G, Tomelleri G, Mari L, Perrone D, Medici A, Neri M,
Bovolenta M, Martoni E, Maraldi N, Bonaldo P, Gualandi F, Merlini L,
Tondelli L, Sparnacci K, Caputo A, Laus M, Ferlini A (2008). The Systemic Administration of a Low Dose of
20meps-AON Combined with Novel Cationic Polymethylmethacrylate
Nanoparticles Induces the Rescue Of Dystrophin Expression in the Mdx Murine
Model. Neuromuscular
Disorders, Vol. 18; P. 758-759, Issn: 0960-8966
-Voltan, Rebecca, Castaldello, Arianna, Brocca-Cofano,
Egidio, Altavilla, Giuseppe, Caputo, Antonella, Laus M, Katia
Sparnacci (2007). Preparation
and Characterization of Innovative Protein-Coated Poly(Methylmethacrylate)
Core-Shell Nanoparticles for Vaccine Purposes. Pharmaceutical Research, Vol. 24; P. 1870-1882,
Issn: 0724-8741
-Alberti A, Benaglia M, Fischer H, Guerra M, Laus M,
Macciantelli D, Postma A, Sparnacci K (2006). An Esr Approach to the Estimation of the Rate
Constants of the Addition and Fragmentation Processes Involved in the Raft
Polymerization of Styrene. Helvetica
Chimica Acta, Vol. 89; P. 2103-2118, Issn: 0018-019x
-Castaldello A, Brocca-Cofano E, Voltan R, Triulzi C,
Altavilla G, Laus M, Katia Sparnacci (2006). Dna Prime and Protein Boost Immunization
with Innovative Polymeric Cationic Core-Shell Nanoparticles Elicits Broad
Immune Responses and Strongly Enhance Cellular Responses of Hiv-1 Tat Dna
Vaccination. Vaccine, Vol. 24; P.
5655-5669, Issn: 0264-410x
-Chiarantini L, Cerasi A, Millo E, Sparnacci K, Laus M, Riccio M (2006). Enhanced Antisense Effect of Modified Pnas Delivered Through Functional PMMA Microspheres. International Journal Of Pharmaceutics, Vol. 324; P. 83-91, Issn: 0378-5173
Patents
-Laus M,
S. Weinberg, T. Poggio, V. Kapeliouchko (2008). PTFE-Based Compositions. Us 2008/0275162 A1. Solvay Solexis
-B.
Ensoli, A. Caputo, Laus M, L. Tondelli, K. Sparnacci, R. Gavioli
(2007). Use Of Microparticles For
Antigen Delivery. Us
Patent Application No: 2007/0275,071. Istituto Superiore Di Sanita
-Palamone
G, Poggio T, Kapeliouchko V, Laus M (2007). Tetrafluoroethylene
Polymer Particles. Ep1849809a1.
Solvay Solexis
-Schwab T, Weinberg S,
Poggio T, Kapeliouchko V, Laus M (2007). PTFE Based Compositions. Wo2007/065880a2. Solvay
Solexis
-Tiziana Poggio, Valerj Kapeliouchko, Laus M
(2007). PTFE Based Compositions.
Wo 2007/065880 A2. Solvay Solexis
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