Lorenzo Tei
Department of Science and Technological Innovation
University of Piemonte Orientale "Amedeo Avogadro"
Street Address - 15121 - Alessandria - Italy
| Telephone: | +39 0131 360 208 |
| Faximile: | +39 0131 360 250 |
| Email: | lorenzo.tei@mfn.unipmn.it |
Brief Curriculum Vitae
Born in
PROFESSIONAL
EXPERIENCE
2006 - present:
Department of Scienze ed Innovazione Tecnologica, University of Piemonte
Orientale, Alessandria, Italy
Associate Professor in Organic Chemistry (since 2015) working on the synthesis
and optimization of Magnetic Resonance Imaging (MRI) contrast agents and on the
development of probes for MR-molecular imaging applications.
During
2011, he had been member of the Commission for the revision of the
Statute of
the
2003
- 2006:
Department
of Internal Medicine, University of Torino, Italy,
Post-doc in a scientific team formed by chemists and molecular
biologists on a
project for the development of biotechnologies and pharmaceuticals for
the
improvement of cancer diagnosis, monitoring and therapy.
2004-05:
worked for Bracco S.p.A at the Department of Chemistry IFM,
2001
- 2002:
Department
of Inorganic and Analytical Chemistry,
Post-doc. In charge of a research project regarding the synthesis of new
molecules
for biomedical and technological applications.
EDUCATION
1997
- 2001:
PhD in Chemistry, Supervisor: Professor Martin Schröder.
Title: Synthesis and coordination chemistry of macrocyclic
receptors having
numerous applications.
The project included the synthesis and characterization of new
macrocyclic
ligands and the study of their lanthanide complexes as contrast agent
for MRI.
Novel macrocyclic ligands for the synthesis of inorganic polymeric
networks
were also synthesized and studied.
1991
- 96
University of
Research
He is author and
co-author of 85 peer-reviewed papers published
on international journals, 2 patent and 2 chapters of books on Molecular
Imaging (H-index 23, 1650 citations). He participated with 17
oral and several poster presentations at international and national
conferences. He was invited to take seminars in foreign universities
(Nottingham,
Main expertise in Organic and Bioinorganic Chemistry,
in particular in the synthesis, characterization and application of derivatives of polyaminocarboxylic ligands to be used
for the preparation of metal complexes to be used as contrast agents in
Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET).
Design and synthesis of new chelating ligands for the
optimization of the contrast efficiency.
Functionalization of ligands and complexes for the
conjugation, anchoring or encapsulation of the complexes on peptides, proteins,
lipidic orgaic or inorganic nanoparticles.
Synthesis of modified peptides or small organic
molecules to be used as vectors in Molecular Imaging applications.
More recently, he worked on the synthesis of porous
organic frameworks for gas storage and optoelectronic applications.
2014: Alexander Von Humboldt Fellowship
for Experienced Researchers at Klinikum Rechts der Isar, Technische Universität
München in
collaboration with Prof. M. Schwaiger on “A
combined PET-MRI study for an improved, simultaneous characterization of tumor
neoangiogenesis” (2015-2017)
2001: Awarded The J. J. Turner Prize for PhD Thesis Excellence for the best
thesis submitted at the
AFFILIATIONS:
Member of: The European Society for Molecular Imaging; The Italian Chemical Society, The Italian Group of Discussion on Magnetic Resonances (GIDRM)
Member of the EU COST Action TD 1004 (2012-2016): “Theranostics imaging and therapy: an action to develop novel nanosized systems for imaging-guided drug delivery”
He has been member of the EU COST Actions: “Lanthanide Chemistry for Diagnosis and Therapy” (COST D18, 2001-2005) and "Metal-Based Systems for Molecular Imaging Applications" (COST D38 2006-2011).SCIENTIFIC COLLABORATIONS:
Prof. Silvio Aime and Enzo Terreno Molecular Biotechnology Center, University of Torino.
Prof. Markus Schwaiger and Hans-Jurgen Wester, Klinikum Rechts der Isar and Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, München, Germany
Bracco Imaging S.p.A., world leader in MRI diagnostics, BioIndustry Park (Ivrea, TO).
Dr Zsolt Baranyai and Prof. Imre Toth’s group, University of Debrecen, Hungary.
Prof. G. Cravotto and A. Barge, Dipartimento di Scienza del Farmaco, University of Torino.
Pubblications (last 3 years)
1) L.
Chaabane, L. Tei, L. Miragoli, L. Lattuada, M. von Wronski, F. Uggeri, V.
Lorusso, S. Aime, In Vivo MR Imaging of fibrin in a neuroblastoma tumor model by
means of a targeting Gd-containing peptide, Mol Imaging Biol, 2015,
DOI: 10.1007/s11307-015-0846-4.
2) L.
Tei, Z. Baranyai, L. Gaino, A. Forgács, Adrienn Vágner, M. Botta, Thermodynamic stability, kinetic inertness
and relaxometric properties of monoamide derivatives of lanthanide(III) DOTA
complexes, Dalton Trans., 2015, 44, 5467-5478.
3) M. Errahali, G. Gatti, L. Tei, M. Cossi, L. Marchese, D.
Valtolina, P. Saleri, Preparing porous organic polymer capable of adsorbing gas
involves reacting monomer with Friedel-Crafts catalyst in aprotic organic
solvent and with formaldehyde dimethyl acetal, 2015, EP2829319-A1; WO2015011654-A1.
4) F.
Carniato, L. Tei, S. Phadngam, C. Isidoro, M. Botta, NaGdF4 nanoparticles coated with functionalised
ethylenediaminetetraacetic acid as versatile probes for dual optical and
Magnetic Resonance Imaging, ChemPlusChem,
2015, 80, 503-510.
5) R.
Negri, Z. Baranyai, L. Tei, G. B. Giovenzana, C. Platas-Iglesias, A. C. Bényei,
J. Bodnár, A. Vágner, M. Botta, Lower
denticity leading to higher stability: structural and solution studies of
Ln(III)–OBETA complexes, Inorg. Chem., 2014, 53, 12499–12511.
6) M. Errahali, G. Gatti, L. Tei, G. Paul, G. A. Rolla,
L. Canti, A. Fraccarollo, M. Cossi, A. Comotti, P. Sozzani, L. Marchese, Microporous Hyper-Cross-Linked Aromatic
Polymers Designed for Methane and Carbon Dioxide Adsorption, J. Phys. Chem. C, 2014, 118,
28699–28710.
7) G.
Ferrauto, F. Carniato, L. Tei, H. Hu, S. Aime and M. Botta, MRI nanoprobes based on chemical exchange
saturation transfer: LnIII chelates anchored on the surface of
mesoporous silica nanoparticles, Nanoscale,
2014, 6, 9604-9607.
8) J.
Martinelli, K. Thangavel, L. Tei, M. Botta, Dendrimeric beta-cyclodextrin / GdIII chelates supramolecular
host-guest adducts as high-relaxivity MRI probes, Chem. Eur. J., 2014, 20, 10944-10952.
9) M.
Errahali, G. Gatti, L. Tei, L. Canti, A. Fraccarollo, M. Cossi and L. Marchese,
Understanding Methane Adsorption in
Porous Aromatic Frameworks: An FTIR, Raman, and Theoretical Combined Study,
J. Phys. Chem. C, 2014, 118, 10053-10060.
10) M.
Filippi, J. Martinelli, G. Mulas, M. Ferraretto, E. Teirlinck, M. Botta, L.
Tei, E. Terreno Dendrimersomes: a new
vesicular nano-platform for MR-molecular imaging applications, Chem Commun., 2014, 50, 3453-3456
11) Z.
Baranyai, G. A. Rolla, R. Negri, A. Forgács, G. B. Giovenzana, L. Tei, Comprehensive Evaluation of the
Physicochemical Properties of LnIII Complexes of Aminoethyl-DO3A as
pH-Responsive T1-MRI
Contrast Agents, Chem. Eur. J., 2014, 20,
2933-2944
12) G.
Gambino, S. De Pinto, L. Tei, C. Cassino, F. Arena, E. Gianolio, M. Botta, A new ditopic GdIII complex
functionalized with an adamantly moiety as a versatile building block for the
preparation of supramolecular assemblies, J. Biol. Inorg. Chem. 2014, 19, 133–143
13) A.
Ermelindo, G. Gambino, L. Tei, Synthesis
of a mixed carboxylate-phosphinate AAZTA-like ligand and relaxometric
characterization of its GdIII complex, Tetrahedron Lett., 2013, 54, 6378-6380
14)
G. A. Rolla, M. Botta, L. Tei, C. Cabella, S. Ghiani,
C. Brioschi, A. Maiocchi,
Paramagnetic Solid Lipid Nanoparticles as a novel platform for the development
of molecular MRI probes, Chem. Eur. J., 2013, 19, 11189 – 11193
15) G. Gambino, J. Engelmann, L. Tei, M. Botta, N. K.
Logothetis, I. Mamedov, Multimodal Contrast Agents for In Vivo
Neuroanatomical Analysis of Monosynaptic Connections, Biomaterials,
2013, 34, 7135-7142
16) E. Cittadino, M. Botta, L. Tei, F. Kielar, R.
Stefania, E. Chiavazza, S. Aime, E. Terreno, In vivo 1 T MRI detection of
paramagnetic liposomes loaded with amphiphilic Gd(III)-complexes: impact of molecular
structure on relaxivity and excretion efficiency, ChemPlusChem, 2013, 78, 712-722
17) F. Carniato, K. Thangavel, L. Tei, M. Botta, Structure
and dynamics of the hydration shells of citrate-coated GdF3
nanoparticles, J. Mater. Chem. B, 2013, 1, 2442-2446
18)
F. Casalini, L. Fugazza, G. Esposito, C. Cabella, C.
Brioschi, A. Cordaro, L. D'Angeli, A. Bartoli, M. Filannino, C. Gringeri, D.
Longo, V. Muzio, E. Nuti, E. Orlandini, G. Figlia, A. Quattrini, L. Tei, G.
Digilio, A. Rossello, A. Maiocchi, Synthesis and Preliminary Evaluation in
Tumor Bearing Mice of New [18F]-labelled Arylsulfone Matrix
Metalloproteinase Inhibitors as Tracers for Positron Emission Tomography, J. Med. Chem. 2013, 56, 2676-2689
19) G. A. Rolla, C. Platas Iglesias, M. Botta, L. Tei,
L. Helm, 1H and 17O NMR relaxometric and computational
study on macrocyclic Mn(II) complexes, Inorg.
Chem., 2013, 52, 3268-3279
20) N. Vologdin, G. A. Rolla, M. Botta, L.Tei, Orthogonal
synthesis of a heterodimeric ligand for the development of the GdIII/GaIII ditopic
complex as potential pH-sensitive MRI/PET probe Org. Biomol. Chem., 2013, 11, 1683-1690
21) F.
Carniato, L. Tei, A. Arrais, L, Marchese, M. Botta Selective anchoring of GdIII-chelates on
the external surface of organo-modified mesoporous silica nanoparticles: a new
chemical strategy to enhance relaxivity, Chem. Eur. J.,
2013, 19, 1421-1428
22) L. Tei, Z. Baranyai, C. Cassino, M. Fekete, F. K.
Kalman, M. Botta, Solution properties of the LnIII complexes of a
novel octadentate chelator with rigidified iminodiacetate arms, Dalton
Trans., 2012, 41, 12797-12806
23) M.
Cossi, G. Gatti, L. Canti, L. Tei, M. Errahali, L. Marchese, Theoretical prediction of high pressure
methane adsorption in porous aromatic frameworks (PAFs). Langmuir, 2012, 28, 14405-14414
24) Z. Baranyai, M. Botta, M. Fekete, G. B. Giovenzana,
R. Negri, L. Tei, C. Platas-Iglesias, Lower ligand denticity leading to
improved thermodynamic and kinetic stability of the Gd3+ complex:
the strange case of OBETA, Chem. Eur. J., 2012, 18, 7680-7685
25) M. Botta and L. Tei, Relaxivity Enhancement
in Macromolecular and Nanosized GdIII-Based MRI Contrast Agents,
Eur. J. Inorg. Chem., 2012, 1945-1960
26) G. B. Giovenzana, R. Negri, G. A. Rolla, L. Tei, Gd-Aminoethyl-DO3A
Complexes: A Novel Class of pH-Sensitive MRI Contrast Agents, Eur. J.
Inorg. Chem., 2012, 2035-2039
27) L. Tei, G. A. Rolla, G. Gugliotta, M. Botta, One-pot
synthesis of a piperidine-based rigidified DTPA analogue and its bifunctional
chelating agent, Org. Biomol. Chem., 2012, 10, 2525-2527
28) J. Martinelli, G. Gugliotta, L. Tei, Synthesis
of 6-Substituted-6-Nitroperhydro-1,4-diazepines via Novel Tandem Retro-Henry
and Mannich/Michael Reactions, Org. Lett., 2012, 14, 716-719
29) Z. Baranyai, L. Tei, G. B. Giovenzana, F. K.
Kalman, M. Botta, Equilibrium and NMR relaxometric studies on the s-Triazine-Based
heptadentate ligand PTDITA showing high selectivity for Gd3+ ions,
Inorg. Chem., 2012, 51, 2597-2607
Projects
He was responsible for a Research Project with Metheresis Translational Research S.A. with title: “Study on the production of imaging probes based on DN30 and FabDN30 antibodies” (2012).
Participation in Compagnia di San Paolo Project (Principal Investigator Prof. M. Botta): Nanoparticles loaded with MRI probes with enhanced efficacy and glycolipids for increased stealth properties (NANOPROGLY) 2013-15.
Participation in Regional Projects (Regione Piemonte) (local coordinator Prof. M. Botta):
-
"Converging technologies" - Nano-sized Systems for Innovative Biotechnological Applications: Imaging-guided Therapy (Nano-IGT), 2009-2012.
-
Platform for Medical Imaging of Piemonte (PIMP): Molecular Imaging Innovative Procedures for Diagnostics and Therapeutic Monitoring, 2009-2012.
-
Applied Medical Research Project: "Development of contrast agents for tumor pathologies diagnosis optimized for the new generation of MRI scanners", 2007-2008.
Applied Medical Research Project (coordinator Dr G. Digilio): "Development of cellular labelling methods for diagnostics via Nuclear Magnetic Resonance, 2008-2009.
Participation in National Projects (local coordinator Prof. M. Botta):
PRIN 2005, “High sensitivity probes for Magnetic Resonance Molecular Imaging applications”, 2005-2007; PRIN 2007, "Smart Probes based on Mn(II) complexes for innovative applications in the field of diagnostic MRI", 2009-2010; PRIN 2009, “Nanosystems for new MRI-guided therapy applications”, 10/2011- 10/2013.
Participation in EU and National Projects (coordinator Prof. S. Aime):
Innovative chemical tools for improved molecular approaches in biomedicine (PRIN 2012)
-
European Networks of Excellence (6th EU Framework Programme): “European Molecular Imaging Laboratories - EMIL” (2004-2009).
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“Diagnostic Molecular Imaging DiMI” (2005-2010).
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MEDITRANS (NMP4-CT-2006-026668), Targeted Delivery of Nanomedicine (2006-2011).
Teaching
He is responsible for Organic Chemistry I course at the first year of the Degree in Chemistry (www.disit.unipmn.it).
From 2006-2007 to 2009-2010 academic years he was responsible for the course of Bioorganic Chemistry at the Master Degree in Chemistry and for the course of Organic chemistry and Laboratory for the Degree in Material Science.
Supervisor and co-supervisor of the following Chemical Sciences PhD students:
G. Gugliotta: “Synthesis and validation of novel probes for MRI-molecular imaging protocols”, 2008-2010; G. Gambino: “Development of high relaxivity Magnetic Resonance Molecular Imaging probes”, 2011-2013; Luca Gaino: “Synthesis of novel parmagnetic reporters for Magnetic Resonance Imaging applications”, 2012-2014; Mina Errahali: “Synthesis and characterization of new microporous polyaromatic materials (PAFs) with high surface area for gas storage and OLED devices applications” 2012-2014.
Tutor of seven Research Theses for the Bachelor Degree in Chemistry and five Research Theses for the Master degree in Applied Chemistry.
Teacher of Solid Phase Peptide Synthesis, Bioconjugation techniques and Bifunctional chelating ligands synthesis for the "European Master in Molecular Imaging (EMMI; www.e-mmi.eu), Intensive Programme "Probes and Models for Imaging Diseases and Therapy", Molecular Biotechnology Center (MBC), Torino, September 2012 and 2013. From 2009 to 2011, he was teacher for the IP: "Design, Synthesis and Validation of Imaging Probes", held at MBC in Torino.
Teacher and co-organizer of the European School “EMIL (European Molecular Imaging Laboratories) Technological Training Platform 2: Imaging Probes Preparation” (5 editions 2005-2009) in Torino, Italy.
Since 2008, he is teacher of Organic Chemistry for Secondary School students within the Training Courses for International Olympic Games in Chemistry (Alessandria).
Teacher at the “Summer School on Advanced Topics in Biomedicine II”, Trieste, 19-21 July 2007; “MRI contrast agents for Molecular Imaging applications”.